Iatrogenic Creutzfeldt-Jakob Disease from Commercial Cadaveric Human Growth Hormone
نویسندگان
چکیده
unvaccinated dogs and in the endangered Simien jackal (Canis simensis) of Ethiopia. Journal of Veterinary Medicine Series B. 1992;39:233–5. http://dx.doi. org/10.1111/j.1439-0450.1992.tb01162.x 7. Zhang YZ, Fu ZF, Wang DM, Zhou JZ, Wang ZX, Lv TF, et al. Investigation of the role of healthy dogs as potential carriers of rabies virus. Vector Borne Zoonotic Dis. 2008;8:313–20. http://dx.doi. org/10.1089/vbz.2007.0209 8. Cleaveland S, Appel MGJ, Chalmers WSK, Chillingworth C, Kaare M, Dye C. Serological and demographic evidence for domestic dogs as a source of canine distemper virus infection for Serengeti wildlife. Vet Microbiol. 2000;72:217– 27. http://dx.doi.org/10.1016/S03781135(99)00207-2 9. Evangelista KV, Coburn J. Leptospira as an emerging pathogen, a review of its biology, pathogenesis and host immune responses. Future Microbiol. 2010;5:1413– 25. http://dx.doi.org/10.2217/fmb.10.102 10. Kolaczinski JH, Reithinger R, Worku DT, Ocheng A, Kasimiro J, Kabatereine N, et al. Risk factors of visceral leishmaniasis in east Africa, a case-control study in Pokot territory of Kenya and Uganda. Int J Epidemiol. 2008;37:344–52. http://dx.doi. org/10.1093/ije/dym275
منابع مشابه
Iatrogenic Creutzfeldt-Jakob disease: the waning of an era.
The outbreaks of iatrogenic Creutzfeldt-Jakob disease (CJD) from cadaveric human growth hormone and dura mater are winding down and, like the only other environmentally acquired form of CJD (variant CJD due to infection with the agent of bovine spongiform encephalopathy), iatrogenic disease seems to have reached its high water mark during the 1990s. The total number of cases has reached 405, an...
متن کاملCan Creutzfeldt-Jakob disease unravel the mysteries of Alzheimer?
Recent studies on iatrogenic Creutzfeldt-Jakob disease (CJD) raised concerns that one of the hallmark lesions of Alzheimer disease (AD), amyloid-β (Aβ), may be transmitted from human-to-human. The neuropathology of AD-related lesions is complex. Therefore, many aspects need to be considered in deciding on this issue. Observations of recent studies can be summarized as follows: 1) The frequency ...
متن کاملCreutzfeldt-Jakob disease with unusually extensive neuropathology in a child treated with native human growth hormone
We report a case of iatrogenic Creutzfeldt-Jakob disease(iCJD) in a child with a neonatal growth hormone (GH) deficiency that was treated with native human growth hormone (hGH) between the ages of 9 months and 7 years. Three years after the end of treatment a progressive neurological syndrome consistent with Creutzfeldt-Jakob disease (CJD) developed, leading to death within a year, at age 11. N...
متن کاملHuman growth hormone-related iatrogenic Creutzfeldt-Jakob disease with abnormal imaging.
BACKGROUND Although more than 160 cases of iatrogenic Creutzfeldt-Jakob disease (iCJD) from human growth hormone (hGH) treatment have been documented, to our knowledge abnormal cerebellar findings on magnetic resonance imaging (MRI) have not been reported. OBJECTIVE To report a case of hGH-related iCJD with abnormal cerebellar MRI findings on fluid-attenuated inversion recovery (FLAIR) and di...
متن کاملA further British case of growth hormone induced Creutzfeldt-Jakob disease.
Transmission of Creutzfeldt-Jakob disease (CJD) from cadaveric growth hormone injections had previously been reported in 7 cases, including one from Britain. As a result, the treatment was abandoned in 1985 and superceded by safer recombinant DNA growth hormone injections. Recent reports now record the number of cases worldwide as 23, but with the incubation period being measured in years, new ...
متن کاملEarly cognitive decline in Creutzfeldt-Jakob disease associated with human growth hormone treatment.
BACKGROUND Most cases of Creutzfeldt-Jakob disease (CJD) in recipients of human cadaveric growth hormone present with a cerebellar syndrome. Dementia is thought to occur late and as a minor feature of the illness. However, neuropsychology data published on these cases are largely qualitative and anecdotal. The first published case does include a neuropsychological assessment seven months after ...
متن کامل